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( Executive/Senior Director Level)
Position Summary
The Head of Translational Development for the Tumor Microenvironment Modulation (TME) Thematic Research Center (TRC) will be responsible for developing the translational research and clinical biomarker strategy in alignment with both discovery and early clinical development objectives, as well as clinic-ready target engagement and pharmacodynamic biomarker assays for all therapeutic candidates within the TME Modulation TRC. This strategy will influence initial patient selection or stratification hypotheses for preclinical drug development programs within the TME Modulation TRC which develops therapeutic targets at the intersection of tumor, stromal and immune biology with the TME to enhance responsiveness to checkpoint blockade and other targeted therapies.
Roles & Responsibilities
Lead of team of 30-45 scientists and effectively collaborate with other TME Modulation TRC discovery as well as colleagues in supportive line functions (including discovery biotherapeutics, translational medicine, early clinical development and project leadership) to advance preclinical development of therapeutic candidates and develop high quality biomarker strategies as well as clinic-ready companion target engagement and pharmacodynamics (proximal and distal) biomarker assays for all development candidate programs within the TRC.
Ensures the output of the biomarker plans meets established program standards (within budget, on schedule, compliance, etc.), while also looking for opportunities to streamline progress without compromising quality.
This function will also encompass the individuals that will serve as program biomarker leads, in collaboration with the Translational Development and Precision Medicine organization, as programs emerging from the TRC move through early clinical development.
Working with Early Clinical Development and Project Leadership colleagues, proactively sets the strategy and provides insight into novel ways to incorporate biomarkers into clinical designs to enable early understanding of emerging drug profiles.
Communicates key biomarker program information, risks, and milestones, and manage information flow across key stakeholders including therapeutic area leadership, functional leads and team members.
Play a key role in providing the relevant strategic translational input to discovery projects as part of interdisciplinary teams comprising research biology, bioinformatics, histopathology and genomics, with a particular emphasis on human TME biology, to increase the probability of technical success of TME modulating agents or combinations thereof in patients that are resistant to checkpoint blockade therapy
Scope of Role and Responsibilities
TME TRC portfolio mechanism of action, disease biology and translational hypothesis support
Tumor explant / histoculture assays to generate PD and MoA data in context relevant to primary human disease
Development of clinic-ready patient selection and PD assays
Oversee the execution of exploratory biomarker assays
TRC-dedicated IHC/histology and NGS/Gene manipulation
Experience
MD, PhD or MD/PhD or equivalent advanced biology degree with 12+ years of experience in the drug development
Biology drug hunting expertise needed to lead both small and large molecule programs from early target identification through to IND submission
Deep understanding of the role of translational research/medicine and clinical biomarkers in drug development.
Experience in the design and generation of clinic-ready biomarker assays in the field of Oncology
Bristol-Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees the resources to pursue their goals, both at work and in their personal lives.
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