Head of Respiratory Pharmacology

Head of Respiratory Pharmacology

Position Summary:

Arcturus Therapeutics is seeking an innovative and highly motivated Respiratory Pharmacologist to join our team. The successful candidate will help build a new class of lung targeted products based on Arcturus’s proprietary Lipid Nano Particle (LNP) nucleic acid delivery platform. The successful candidate must have a track record of experience in identifying, validating and advancing aerosolized drugs into the clinic.

The successful candidate will thrive in a proactive, fast-paced ‘can-do’ culture and enjoy collaborating across the full range of development activities and project teams for the ground-breaking, mRNA-based new drug candidates targeting respiratory diseases. This is a Director/VicePresident-level role and our candidate should have extensive experience in thedevelopment of aerosolized drug delivery systems with a proven track record ofprogressing programs from preclinical to clinical stages. Must thrive working in a fast-paced, innovative environment while remaining flexible, proactive, resourceful and efficient. Excellent interpersonal skills, ability to develop important relationships with key stakeholders, good conflict management and negotiation skills, ability to identify and troubleshoot issues and raise to key stakeholders in order to develop relevant and realistic plans, programs and recommendations.

Responsibilities:

• Lead Arcturus’s inhaled drug discovery and development platform in the respiratory therapeutic area to progress products into the clinic.
• Collaborate across multiple internal teams to identify and interrogate respiratory target pathways using novel approaches to enrich our pipeline.
• Lead programs and projects addressing key scientific questions, execution of research plans, risk assessments and data-driven decisions.
• Provide strategic, scientific leadership in the design, execution, analysis, and interpretation of a broad range of in vitro, in vivo and ex vivo experiments for drug discovery.
• Effectively identify, develop and manage collaborators (academic, industrial partners and CROs).
• Critically analyze and interpret data, effectively document and communicate results to diverse audiences, internally and externally.
• Build and develop future talent by providing mentorship and regular coaching to team members.

Qualifications:

• Ph.D. with 15+ years’ experience in the respiratory field with an emphasis on target ID, validation, and preclinical drug development for the respiratory-based disease.
• Experience within Vivo aerosolized drug delivery optimization.

· Understanding of classical pharmacological principles and drug discovery process, in order to support the assessment of potency, efficacy and contribute to predictions of human efficacy.

· Experience with animal models of respiratory disease.

· Design and interpret in vivo pharmacology studies to evaluate the activities of drug candidates, investigate their mechanisms of action, and explore novel therapeutic hypotheses.

· Experiencewith pharmacodynamics endpoints, such as biomarkers or in vivo imaging, is a plus.

· Investigate, select, and/or develop new methods and technologies for project advancement; monitor work-flows to enable execution of studies.

· Managein Vivo pharmacology research in a matrixed environment, as well as external academic collaborations and an extensive network of CROs.

· Demonstrated ability to translate strategy into action; excellent analytical skills and an ability to communicate complex issues in a simple way and to orchestrate plans to resolve issues and mitigate risks.

· Excellent presentation and oral and written communication skills is required.

· Ability to prioritize and work in a fast-paced and diverse environment is required.

· Strong sense of urgency, initiative, ethics/integrity, and innovation is required.

About Us:

Founded in 2013 and based in San Diego, Arcturus Therapeutics Inc.is a publicly-traded RNA medicines company. We are developing a portfolio of RNA therapeutics for the treatment of diseases with high unmet medical needs. Our team has extensive experience in the discovery and development of RNA medicines, as well as the design and utilization of lipid-mediated drug delivery systems. This combination of in-house expertise, innovative spirit, and passion for what we do, uniquely positions us to catalyze the next generation of RNA medicines. Arcturus’ commitment to the development of novel RNA therapeutics has led to partnerships with Janssen Pharmaceuticals, Inc., part of the Janssen Pharmaceutical Companies of Johnson & Johnson, Ultragenyx Pharmaceutical, Inc., Takeda Pharmaceutical Company Limited, and the Cystic FibrosisFoundation.

Arcturus is committed to equal opportunity and complies with all applicable national, state and local laws governing nondiscrimination inemployment. Arcturus is an eVerify employer.

Job Type: Full-time

Experience:

• relevant: 10 years (Required)

Education:

• Doctorate (Required)

Work authorization:

• United States (Required)

Work Location:

• One location

Benefits:

• Health insurance
• Dental insurance
• Vision insurance
• Retirement plan
• Paid time off
• Parental leave